ea0092op-01-01 | Oral Session 1: Highlights in Thyroidology: in Memory of Jacques Dumont | ETA2023
Jager Eline
, Sondorp Luc
, Antunes Ines
, Jansen Liesbeth
, Brouwers Adrienne
, Links Thera
, Coppes Robert
, Kruijff Schelto
Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. Mutations in the gene encoding the Rearranged during Transfection (RET) tyrosine kinase, play a vital role in the development of MTCs. In patients with distant metastases, only targeted therapy can prolong survival. Tyrosine kinase inhibitors (TKIs) block tyrosine kinases such as RET and thereby inhibit tumor proliferation. However, it is diffic...